Sometimes the joy of meeting friends is enough, even periods of relaxation after stressful situations can cause a migraine attack. The disease can not be cured, but there are now ways to reduce the frequency and severity of migraine attacks. Until now, the prophylactic treatment spectrum consisted of non-drug treatment options and migraine non-specific drugs, which were actually approved for the treatment of other diseases such as hypertension, epilepsy or depression. But then they also showed positive effects in migraine. Nevertheless, drug-based prophylaxis has been rather unsatisfactory to date.