Study program & # 39; s: many brain diseases are genetically related
An international study has shown that genetic relationships exist between certain brain diseases. This increases the risk of developing a correspondingly correlated disease in the case of disease.
Mental illnesses are widespread
According to health experts, every fourth person suffers a mental disorder such as depression at some point in his life. Scientific research has shown that we all have the facilities for this. If you suffer from such a disease, there is a high risk of a new psychiatric or neurological disorder. Because many brain diseases are genetically related to each other.
Genetic relationships between certain diseases
In a worldwide study of the international "Brainstorm Consortium", the genome of 1.1 million patients with psychiatric and neurological disorders was analyzed for the first time.
As stated in a communication from the Medical University (MedUni) Vienna, it can be demonstrated that genetic relationships exist between certain brain diseases.
For example, psychiatric disorders such as anxiety disorders and depression correlate significantly with each other.
The results of the research were recently published in the journal "Science".
"There is no" pure "depression"
The diagnosis of psychiatric disorders, such as anorexia, depression or schizophrenia, is predominantly phenotypically based on the symptoms.
However, this usually resulted in a certain blurring, because many classification models do not adequately describe the actual diseases.
Andreas Karwautz, child and adolescent psychiatrist at the University Department of Child and Adolescent Psychiatry of MedUni Vienna and co-author of the study explained:
"There is no" pure "depression or" pure "anorexia that shows no symptoms of other mental disorders, and a diagnosis is always heterogeneous."
Analysis of data on the genome of more than a million people
The international research by the Brainstorm Consortium, a collaboration between various research groups at Harvard University and the Massachusetts Institute of Technology, has now analyzed data on the genome of approximately 265,000 psychiatric and neurological patients and 785,000 healthy individuals.
According to the information, it was investigated whether diseases with certain genetic characteristics are related to each other. For the current study, the general genetic manipulation of a total of fifteen neurological and ten psychiatric disorders was discussed.
Data from patients with eating disorders at the University Department of Child and Adolescent Psychiatry came from MedUni Vienna.
The authors of the study concentrated on three research areas: psychiatric and neurological disorders were considered as separate groups and subsequently compared.
Great genetic similarities
The main finding was that some psychiatric disorders have a high genetic similarity, which increases the risk of developing the correlated disease in case of illness.
This applies to schizophrenia, depressive episodes, bipolar disorder, anxiety disorder and attention deficit syndrome (ADHD), but not to Tourette syndrome and autism.
These showed hardly any genetic correlations. Depression and anxiety are in turn genetically closely related, even if the symptoms are different.
The same applies to anorexia and obsessive-compulsive disorder, as well as schizophrenia and bipolar disorder.
As a result of the second focus, neurological disorders are generally genetically different in their group with respect to each other.
The third analysis of the center of gravity showed that they are also genetically different from psychiatric disorders, with the exception of migraine. There were correlations with ADHD, Gilles de la Tourette syndrome and depressive episodes.
The study thus showed that overlaps occur in specific genetic systems, which again challenges the traditional diagnostic classifications.
Likewise, it can be deduced from the material that genetically correlated diseases, such as psychosis, have similar symptoms that occur in both schizophrenia and Alzheimer's disease.
"This genomic analysis with relevant high case numbers is the first basis for improving psychiatric classification models by means of neurobiologically based diagnostics," says Karwautz. (Ad)