One of the ground-breaking genetic studies of acne has shown that the disease that affects millions of teenagers and adults can have a genetic basis. This genetic study can also pave the way for a new and accurate treatment for researchers who promise acne. The study results are published in the last issue of the journal Nature Communications.
Close-up of acne on the skin. Image Credit: KirinIsHappy / Shutterstock
For this study, the research team of the biomedical research center of the National Institute for Health Research (NIHR) in Guy & # 39; s and St. Thomas & # 39; hospital looked at 26,722 individuals, of which 5,602 people had severe acne. They noted that there was a genetic signature among people with severe acne. These multiple genetic variants influence the formation of hair follicles that influence the risk of acne. The team discovered that some people have a different form of hair follicles that make them more susceptible to developing acne because they can harbor the bacteria that can cause acne.
Acne usually affects 80 percent of people between the ages of 11 and 30 and there are several causes of this condition, including hormonal, bacterial infections, oily skin, etc. These statistics come from the NHS. According to the American Academy of Dermatology, 85 percent of Americans with acne belong to the age group of 12 to 24 years. The skin may become hot and sore and some spots may leave scars after they have been cured. At present, the treatment of acne isotretinoin-containing medications. However, these preparations are not free of side effects or side effects such as muscle pain, dehydration of the skin, etc. They are particularly harmful to the unborn baby when used by pregnant women.
Study leader and dermatologist Prof. Jonathan Barker said there has been some progress in the research into acne in recent decades. He said in a statement: "Applying these genetic approaches to acne has never been done before, and it's a big leap forward, and if you understand the genetic basis of a condition, you can develop much more effective treatments." stressed that early treatment of acne can also prevent the formation of scars that often occur in people with severe acne after the acne has disappeared. The team noted that there were 15 genetic sites susceptible to acne. Of these, 12 were identified for the first time in this study.
Co-author Professor Michael Simpson, who is leader of the Genomic Medicine Group at the King's College in London, said in a statement: "Some of the genetic variants point to interesting mechanisms that can be really good targets for new medicines or treatments that would really help patients. "
The authors wrote in their paper: "Acne can have serious emotional and psychological consequences and is associated with depression, unemployment, suicidal thoughts and suicide itself.The treatment regimens are often ineffective and poorly tolerated, and there is still a considerable unmet medical need . "
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