Could this be the fountain of youth? Drug that clears dead cells left mice more active with lower levels of inflammation
- Researchers at the Weizmann Institute of Science in Israel have investigated how the immune system clears out aging cells
- These cells are not completely dead but are irreparably damaged
- They have given a drug that blocked a certain protein, which means that aging cells can normally thrive
A drug that helps the immune system to clear away old cells could, according to a new study, restore youthfulness.
The research suggests that it is possible to reverse the aging process and possibly pave the way for anti-aging treatments that really work.
Researchers at the Weizmann Institute of Science in Israel examined the way the immune system is involved in clearing old, aging (or aging) cells that are not completely dead but are irreparably damaged and barely functioning.
Within a few weeks, those who received the new drug from the team had fewer aged cells, lower levels of inflammation, and were more active.
There are certain proteins in the body that can nourish aging cells, allowing them to thrive. A team in Israel gave mice a drug that blocked that protein, and left them younger
Senescent cells have been linked to aging diseases by promoting inflammation.
For the study, published in Nature Communications, scientists used two sets of mice.
The first group consisted of mice that lacked a crucial gene that was needed to wipe out aging cells. The second group had the gene.
In two years, which is elderly for mice, the first group had a larger accumulation of age cells compared to the mice in the second group.
The first members also had chronic inflammation, different functions in their body were reduced, they looked older and had a shorter life expectancy than their healthy counterparts.
The accumulation of age cells in these mice is accompanied by a progressive state of chronic inflammation, followed by increased tissue fibrosis and other types of tissue damage, as well as impaired organ functionality. "Said Dr. Valery Krizhanovsky, professor of molecular cell biology at Weizmann and lead author of the study.
De The poor health of old mice is associated with fitness reduction, weight loss, kyphosis, older appearance and a shorter lifespan than those of the other mice. & # 39;
There are certain proteins in the body that can fuel aging cells, allowing them to thrive even though they are essentially meaningless.
The Dr. Krizhanovsky gave a portion of the mice a drug that inhibits the function of these proteins.
The treated mice responded exceptionally well to the drug – their blood tests and activity tests showed improvement and their tissues shared many more similarities with the more juvenile mice.
The scientists found far fewer senescere cells in the bodies of the treated mice and their inflammation level had fallen sharply.
In addition, the mice treated with the drug were more active and increased their average lifespan.
The researchers believe that if future experiments show that their theories are right, they can eventually create genuine anti-aging therapies.
Dr. Krizhanovsky said: De The pharmacological elimination of age cells from these mice prolonged their life span.
& # 39; These findings demonstrate the importance of immune clearance of age cells for the aging process, as well as the relevance and potential promise of pharmacological elimination of age cells in countering age-dependent phenotypes. & # 39;