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sleeping well protects the arteries



Good night's rest promotes cardiovascular health. But for what reason? Researchers have identified a mechanism in the mouse that would explain this phenomenon; it is a peptide produced by the brain that works on the bone marrow and the blood vessels.

In France, according toINSERMone in three people suffer from it sleep disorder. But several studies have found a link between problems of sleep and pathologieslike thesleep apnea, the diabetes, the canceras well as cardiovascular diseases. But what cellular and molecular mechanism can explain this link between sleep and cardiovascular health?

In this study published in nature, the researchers of the Harvard Medical School of Boston focused on the hardening of arteriesor atherosclerosis. For this they have worked on the development of genetically modified miceatherosclerosis. Some mice could sleep normally and others were disturbed in their sleep.

Over time, mice that had poor sleep had more lesions in the blood vessels: their plaquesatheroma about a third were bigger. They also had twice as many cells in their blood that were known to be anti-inflammatory, some monocytescompared with other mice. In addition, their level of hypocretin – a neurohormone produced by thehypothalamus – was lower.

Hypocretins or orixins are neuropeptides that derive their name from a contraction between the words "hypothalamus" and "secretines". the neurons of the hypothalamus that produce the hypocretin, have projections that can be directed to other parts of the central nervous system. According to the Bulletin of the Society of Neurosciencehypocretin injection induces the awakening in the rat. Hypocretin plays a role in the sleep and wake up.

Research that opens the way to new treatments

For the authors, sleep regulates the hematopoiesis, ie the production of blood cellsand protects against atherosclerosis in mice. The mechanism is as follows: some cells of the bone marrow, forerunners of White blood cellshave hypocretin receptors; in the presence of hypocretin, the mice have less circulating monocytes and less atherosclerosis. In contrast, mice without hypocretin have more monocytes and atherosclerosis.

The researchers also tested the effect of hypocretin supplementation in mice. As a result, hypocretin allows poorly sleeping mice to produce fewer inflammatory cells and develop smaller lesions compared to non-supplemented mice.

These results suggest that poor sleep is associated with a decrease in the level of hypocretin that promotesinflammation and atherosclerosis. But more work will have to be done to find out whether this link also exists in humans and whether hypocretin can be used therapy.

In statementFilip Swirski, one of the authors of the research, explains: "We have identified a mechanism that allows a hormone of the brain regulates the production of inflammatory cells in the bone marrow to protect the blood vessels from damage. " But for this beneficial effect to take place, a good night's sleep is essential: "This mechanism anti-inflammatory is regulated by sleep and collapses when you regularly disturb sleep or sleep badly. "

What to remember

  • Bad sleep is associated with cardiovascular diseases.
  • In a mouse model, lack of sleep results in larger plaques of atheroma.
  • A hormone produced by the brain, hypocretin, acts on bone marrow cells and reduces atherosclerosis.

Take a nap to prevent hypertension!

Article published by Claire Peltier on December 14, 2010

For National Hypertension Day, take the time to watch your sleep. Hypertension can indeed be linked to a rest that is too short or not very qualitative.

  • View our complete file blood pressure and hypertension

Hypertendus, are you sleeping well? This is the question posed by the French Committee against Arterial Hypertension (CFLHTA) on the occasion of the national day against hypertension.

It is also the title of a book, meant for everyone to realize that sleep helps to regulate it blood pressure. Indeed, the frequency heart and busy lowers during rest phases. Studies have shown that the lack of sleep (less than 7 hours a day) or poor sleep quality (snoring, sleep apnea…) are often associated with hypertension.

Restore your cardiovascular system

in brief naps also appear to have a beneficial effect on the cardiovascular system, while, in contrast to longer naps, sleep & # 39; s in the evening would not be possible.

Interested in your own sleep to improve it can help to keep your heart. Do not hesitate: contact your doctor.

You can also browse through our questions and answers about ithigh bloodpressure.

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