Good night's rest promotes cardiovascular health. But for what reason? Researchers have identified a mechanism in the mouse that would explain this phenomenon; it is a peptide produced by the brain that works on the bone marrow and the blood vessels.
In France, according toone in three people suffer from it . But several studies have found a link between problems of and like the , the , the as well as cardiovascular diseases. But what cellular and molecular mechanism can explain this link between sleep and cardiovascular health?
In this study published in, the researchers of the Harvard Medical School of Boston focused on the hardening of or . For this they have worked on the development of genetically modified mice . Some mice could sleep normally and others were disturbed in their sleep.
Over time, mice that had poor sleep had more lesions in the blood vessels: their plaquesabout a third were bigger. They also had twice as many cells in their blood that were known to be anti-inflammatory, some compared with other mice. In addition, their level of hypocretin – a neurohormone produced by the – was lower.
Hypocretins or orixins are neuropeptides that derive their name from a contraction between the words "hypothalamus" and "secretines". theof the hypothalamus that produce the hypocretin, have projections that can be directed to other parts of the . According to the hypocretin injection induces the awakening in the rat. Hypocretin plays a role in the and wake up.
Research that opens the way to new treatments
For the authors, sleep regulates the hematopoiesis, ie the production ofand protects against atherosclerosis in mice. The mechanism is as follows: some cells of the , forerunners of have hypocretin receptors; in the presence of hypocretin, the mice have less circulating monocytes and less atherosclerosis. In contrast, mice without hypocretin have more monocytes and atherosclerosis.
The researchers also tested the effect of hypocretin supplementation in mice. As a result, hypocretin allows poorly sleeping mice to produce fewer inflammatory cells and develop smaller lesions compared to non-supplemented mice.
These results suggest that poor sleep is associated with a decrease in the level of hypocretin that promotesand atherosclerosis. But more work will have to be done to find out whether this link also exists in humans and whether hypocretin can be used .
InFilip Swirski, one of the authors of the research, explains: "We have identified a mechanism that allows a of the regulates the production of inflammatory cells in the bone marrow to protect the blood vessels from damage. " But for this beneficial effect to take place, a good night's sleep is essential: "This mechanism is regulated by sleep and collapses when you regularly disturb sleep or sleep badly. "
What to remember
- Bad sleep is associated with cardiovascular diseases.
- In a mouse model, lack of sleep results in larger plaques of atheroma.
- A hormone produced by the brain, hypocretin, acts on bone marrow cells and reduces atherosclerosis.
Take a nap to prevent hypertension!
Article published by Claire Peltier on December 14, 2010
For National Hypertension Day, take the time to watch your sleep. Hypertension can indeed be linked to a rest that is too short or not very qualitative.
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Hypertendus, are you sleeping well? This is the question posed by theon the occasion of the national day against hypertension.
It is also the title of a, meant for everyone to realize that sleep helps to regulate it . Indeed, the heart and lowers during rest phases. Studies have shown that the lack of (less than 7 hours a day) or poor sleep quality ( , …) are often associated with hypertension.
Restore your cardiovascular system
in briefalso appear to have a beneficial effect on the cardiovascular system, while, in contrast to longer naps, sleep & # 39; s in the evening would not be possible.
Interested in your own sleep to improve it can help to keep your heart. Do not hesitate: contact your doctor.
You can also browse through our questions and answers about it.