WASHINGTON: Vitamin B3 has the potential to prevent acute kidney damage, a frequently fatal condition without a specific treatment, has found a study.
The condition causes an accumulation of waste products in the blood and an imbalance of fluids throughout the body.
Acute kidney damage, which affects up to 30-40 percent of all hospitalized adults in low-income countries, can occur as a result of conditions that place the body in extreme stress – putting patients, especially at intensive care units, at risk.
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Researchers led by Samir M Parikh of Beth Israel Deaconess Medical Center in the US discovered that levels of nicotinamide adenine dinucleotide (NAD +) – the end result of vitamin B3 after it is taken – decreases in cases of acute kidney injury.
"We were able to detect a decrease in NAD + in the urine of high-risk patients who were either in an intensive care unit or undergoing major surgery and found that oral vitamin B3 could safely increase NAD + in high-risk patients," said Parikh, who is also associate professor of Medicine at Harvard Medical School in the US.
"These findings are very early, but the results suggest that one day we might have a non-invasive test for NAD + status and maybe even treat acute kidney damage by raising the NAD + level," said Parikh.
Researchers made the discovery by studying the metabolic changes related to acute kidney damage in a mouse model.
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In subsequent studies in humans, the team found high urine quinolinate in patients undergoing major surgery at risk of acute renal injury and confirmed this metabolite pattern in a separate study in 329 patients in the intensive care unit who also had a risk of acute kidney injury. .
The team then gave large doses of oral vitamin B3 to 41 patients with cardiac surgery who participated in a Phase 1 pilot study.
"Our results suggest that NAD + biosynthesis is disrupted during human acute renal injury and that raising vitamin B3 levels may be safe and potentially beneficial for patients," said Kamal Khabbaz of BIDMC, who was co-leader of the clinical trial. .
"We have shown that urinary measurements in patients at risk can indicate this worsening and can also predict adverse outcomes.
Restoring NAD + may represent a significant advance for patients at risk for acute renal injury, although further studies are needed to verify these findings, "Khabbaz said.