Taoiseach Leo Varadkar has said that his first words to Pope Francis would be welcome, but there are a number of issues going from human rights to child sex that he also wants to talk about.
Mr Varadkar also said that any information requested by the authorities of the state to investigate child abuse should be made available, whether in Ireland or in the Vatican.
"We want to be sure that there is truth and justice and cure for victims and that must be part of it," he said.
Varadkar said that during his brief meeting with Pope Francis in Dublin Castle on Saturday, he would try to address as many problems as possible.
"I do not want to walk over them or just do them in a symbolic way, I'll have to see how the meeting goes," he said.
Pope Francis must meet victims of sexual abuse during his visit to Ireland during the World Meeting of Families event.
The Pope will be in Ireland this weekend to attend events in Dublin and visit the Knock Shrine in Co Mayo.
At his weekly audience in Vatican City, the Pope asked people to pray for him for his trip to Ireland.
On Monday, the Pope wrote an unprecedented letter to all Catholics in the world, promising that no effort would be spared to prevent sexual abuse and his cover-up.
In the letter, the Pope condemned abuse, treated previous shortcomings to address the problem and begged forgiveness for his own sins in connection with the treatment of abuse.
"We have realized that these wounds never disappear and force us to condemn these atrocities and join forces in uprooting this death culture," he said.
The Pope will address a crowd of about 500,000 people in the Phoenix Park on Sunday as part of the World Meeting of Families.
The event has already been overshadowed by the church's handling of administrative cases of sexual abuse and the withdrawal of the keynote speaker Cardinal Donald Wuerl, who decided not to come to Ireland after a very critical report in the US on the handling of cases of abuse .
He was replaced as a keynote speaker by Archbishop Eamon Martin, who said that scandals of writing fraud in the Catholic Church have led some to feel that they can no longer trust the message of the Church.
Read more: Pope Francis in Ireland
Meanwhile, an Italian cardinal Pietro Parolin, secretary of state at the Vatican, said in an interview with Vaticaannews this afternoon that Pope Francis will encounter an "altered community" during his Irish visit.
"Almost 40 years after the visit of John Paul II, the pope goes to Ireland, he will meet a changed community that has experienced the pain of the abominable suffering of the abuses," he said.
He added: "The Church in Ireland has admitted its shortcomings, its faults and its sins (equipping itself) with a series of measures that will stop the repetition of these atrocities, of these horrors"
Cardinal Parolin said that Pope Francis "always insisted" that the first task of the Church should be to assist victims and "help them rebuild their lives".
He also said that the Pope's visit to Ireland will take place "under the sign of hope".
Thousands are expected to move the line route from & # 39; popemobile & # 39; to decide
Meanwhile, Pope Francis will drive through Dublin city center on Saturday afternoon in his "popemobile", so that the public will have the first opportunity to see the Pope, according to assistant Garda Commissioner Pat Leahy.
Honoredly speaking about RTÉ & # 39; s Today with Miriam, Commissioner Leahy said that this will take place after the pope has finished in Pro Cathedral at about 4:15 PM.
The route goes south on O & # 39; Connell Street, on the O & # 39; Connell Bridge, on the Westmoreland Street and on the Dame Street.
The route then passes Christchurch Cathedral, exit Bridge Street and walk along the Liffey to Church Street to the Capuchin Center, where Pope Francis has a private meeting with homeless families.
Gardaí expects up to 100,000 people in the city center to view the motorcade.
Commissioner Leahy also said that those who appear to see the pope passing through Dublin on Saturday will come "within two or three meters" from the pope.