"We are very sorry for the … cancellation," says the group's statement on its website. "Bono was great in shape for the show, his voice was great and we all waited for the second night in Berlin, but after a few songs he completely lost his voice."
"We do not know what happened and we consult with the doctors," the statement adds.
This was the second and last concert of the band Experience + Innocence in the German capital.
After a few first songs Bono & # 39; s voice struck. The 58-year-old singer stopped singing to spit a drink from the thermos.
The record published on the lifestyle magazine EFTM social network Twitter shows that Bone finally tells the audience: "I think we can not go any further."
"That's wrong with you, it's useless," he said, breaking the show in the group to "talk".
The concert was finally stopped, the audience was told that they could later return to another U2 show.
"As always, we appreciate the understanding of our viewers and the support of all our fans in Berlin and far away, and will soon provide you with updated information," the statement said.
American actress Ashley Judd wrote on Twitter that Bono sang "out of control", "but his voice" suddenly disappeared ".
"The crowd loved him," she added.
Another U2 concert is scheduled for Tuesday in Cologne.
During the first concert in Berlin, which took place on Friday, Bono condemned the recent extreme right-wing violence in the city of East Germany in Chemnitz.
During the concert the motto "#wirsindmehr" ("we are more than that") was designed in the scene, which was used by the participants in the mutual protests in extreme right against Germany. Projection greeted the audience with greetings.
With the slogan Chemnice a German concert "Die Toten Hosen" is organized for a free concert on Monday.