The Jet2 flight returned from Spain last night to Leeds at 9.45 pm when the incident occurred.
After the landing, two ambulances and a team for hazardous areas were sent to the area.
Passengers were allegedly severely ill because of the bug after landing at the airport.
No one was reported to have been taken to the hospital.
A passenger told Yorkshire Evening Post: "We spent almost an hour on the escape route waiting for the emergency services to be present and to make everything clear to us."
Another took Facebook to praise the services of the crew and said that people on board "like flies", according to the BBC.
West Yorkshire Police Sergeant Chris Brumfitt posted a tweet with photo 's at the time of the response.
He wrote: "Joint response from the emergency services at Leeds / Bradford airport tonight after reporting a number of people who became ill during an incoming flight.
"Fortunately nothing more than a disease picture."
A spokesperson for Jet2 confirmed to Express.co.uk: "We can confirm that the crew on board LS298 from Reus to Leeds Bradford Airport arranged an ambulance for two passengers who fell ill.
"The crew was alerted for another two, non-associated cases of passengers feeling unwell on board.
"On arrival they were immediately checked in the ambulance as a precaution before going home.
"All other passengers got off as normal and continued their journey, and the safety and care of our customers is always our first priority."
Diseases can spread very easily in an airplane thanks to the circulating air in the cabin.
However, turning the air vent above a chair may mean that more germs are being collected.
The blasting of the air from the fan above the head can help to push germs into the air that are distributed to the floor by the compartments of the aircraft.
The medical director of Lahey Medical Center-Peabody told Travel + Leisure that it could block particles that spread through the air through the air.
He said: "As a rule of thumb, the air you normally breathe and are exposed to is usually somewhere between two and five rows around your seat."
The air outlet therefore pushes the air down, so you can not get sick.