Large study finds HPV vaccination does not have a negative effect on fertility in adolescents



<p class = "canvas-atom canvas-text Mb (1.0em) Mb (0) – sm Mt (0.8em) – sm" type = "text" content = "PORTLAND, Ore., August 21, 2018 / PRNewswire / – & nbsp; Adolescents receiving recommended vaccines, including for human papillomavirus (or HPV), do not have an increased risk of primary ovarian insufficiency, also called premature menopause, according to a Kaiser Permanente study published today in Pediatrics. "-reactid =" 11 ">PORTLAND, Ore., August 21, 2018 / PRNewswire / – Adolescents receiving recommended vaccines, including for human papillomavirus (or HPV), do not have an increased risk of primary ovarian insufficiency, also called premature menopause, according to a Kaiser Permanente study published today in Pediatrics.

Kaiser Permanente logo. (PRNews picture / Kaiser Permanente) (PRNewsfoto / Kaiser Permanente)

Rates of HPV vaccination lagged behind the coverage rate for other recommended vaccinations for adolescents, such as tetanus diphtheria-acellular pertussis (Tdap) and meningococcal conjugate. Based on national coverage estimates from 2016, 65 percent of 13-17-year-old women received at least one HPV vaccination and only 49.5 percent were up to date with the series, compared to about 88 percent of the adolescents who received Tdap.

Although major studies have demonstrated the safety of HPV vaccination, concerns about parental safety – including possible consequences for future fertility – are often cited as a reason for lower HPV coverage.

<p class = "canvas-atom canvas-text Mb (1.0em) Mb (0) – sm Mt (0.8em) – sm" type = "text" content = "" Reports of premature menopause after HPV vaccination have received a lot media attention, also on social media, "said Allison Naleway, PhD, lead author and researcher at the Kaiser Permanente Center for Health Research Portland, Oregon. "However, these reports were based on a small number of isolated cases and should be interpreted with caution.To clarify this issue, we conducted a survey of nearly 200,000 young women and found no increased risk of POI after HPV or other recommended vaccinations. "" data-reactid = "25"> "Reports of premature menopause after HPV vaccination have received a lot of media attention, also on social media", said Allison Naleway, PhD, lead author and researcher at the Kaiser Permanente Center for Health Research Portland, Oregon. "However, these reports were based on a small number of isolated cases and should be interpreted with caution.To clarify this issue, we conducted a survey of nearly 200,000 young women and found no increased risk of POI after HPV or other recommended vaccinations. "

<p class = "canvas-atom canvas-text Mb (1.0em) Mb (0) – sm Mt (0.8em) – sm" type = "text" content = "Naleway and her team started identifying 199,078 females age 11-34 with at least 30 days membership of the health plan at Kaiser Permanente in the northwest of August 2006 & nbsp; (when HPV vaccines became available at Kaiser Permanente) until the end of 2014. The research period was chosen to maximize the potential number of NP cases. Researchers followed these female members to the dismantling of the health plan, their 35th birthday, or the end of the study period, depending on what first happened. "data-reactid =" 26 "> Naleway and her team started to identify 199,078 women aged 11-34 years with at least 30 days of health plan membership at Kaiser Permanente in the Northwest of August 2006 (when HPV vaccines became available at Kaiser Permanente) until the end of 2014. The research period was chosen to maximize the potential number of NP cases. Researchers followed these female members to the dismantling of the health plan, their 35th birthday, or the end of the study period, whichever was the first.

During the study period, 119,078 women received Tdap, 84,783 received flu vaccine, 5871 received the HPV vaccine and 46,231 received meningococcal conjugate.

<p class = "canvas-atom canvas-text Mb (1.0em) Mb (0) – sm Mt (0.8em) – sm" type = "text" content = "In addition to researching Kaiser Permanente's electronic health database, The researchers have manually assessed the presumed cases of POI they have found. Researchers have excluded cases of POI with a known cause (eg genetic disorders or surgical removal of the ovaries), as well as miscoded diagnoses and cases with symptom onset prior to August 2006. Of the remaining 28 cases, only one prior to the onset of POI symptoms was vaccinated against HPV. "Data-reactid =" 28 "> In addition to studying Kaiser Permanente's electronic health database, the researchers have manually assessed the suspected cases of POI Researchers have excluded cases of POI with a known cause (eg genetic disorders or surgical removal of the ovaries), as well as miscoded diagnoses and cases with symptom onset prior to August 2006. Of the remaining 28 cases, only one was vaccinated against HPV prior to the onset of POI symptoms.

"In a population of 56,771 young women who received the HPV vaccine during the study period, we found only one case of a person who may have symptoms of primary ovarian adequacy after vaccination," said Naleway. "If POI is caused by the HPV vaccine or another recommended vaccine for adolescents, we would expect a higher incidence among the younger women who were most likely to be vaccinated, but we found no increased risk for these individuals."

The study was conducted under the auspices of the Vaccine Safety Datalink, a collaborative project with eight integrated health care systems and the US centers for disease control and prevention.

<p class = "canvas-atom canvas-text Mb (1.0em) Mb (0) – sm Mt (0.8em) – sm" type = "text" content = "" The safety of adolescent vaccines is important for CDC, such as it is for parents and caregivers, "said co-author Julianne Gee, MPH, epidemiologist, Immunization Safety Office, CDC. "Although the safety of these vaccines is well established, this important study provides evidence-based scientific evidence that HPV and other adolescent vaccines do not negatively affect fertility in young women." "Data-reactid =" 31 ">" The safety of adolescent vaccines is important for CDC, as it is for parents and caregivers, "said co-author Julianne Gee, MPH, epidemiologist, Immunization Safety Office, CDC. "Although the safety of these vaccines is well established, this important study provides additional scientific evidence that HPV and other adolescent vaccines do not negatively affect fertility in young women."

The study was supported by the American Centers for Disease Control and Prevention (Task Order 200-2012-53584-0006). The findings and conclusions are those of the authors and do not necessarily represent the official position of the Centers for Disease Control and Prevention.

<p class = "canvas-atom canvas-text Mb (1.0em) Mb (0) – sm Mt (0.8em) – sm" type = "text" content = "About the Kaiser Permanente Center for Health Research
The Kaiser Permanente Center for Health Research, founded in 1964, is a non-profit research institute dedicated to promoting knowledge to improve health. It has research sites Portland, Oregon, and Honolulu. Go to kpchr.org for more information. "Data reactid =" 37 ">About the Kaiser Permanente Center for Health Research
The Kaiser Permanente Center for Health Research, founded in 1964, is a non-profit research institute dedicated to promoting knowledge to improve health. It has research sites Portland, Oregon, and Honolulu. Go to kpchr.org for more information.

<p class = "canvas-atom canvas-text Mb (1.0em) Mb (0) – sm Mt (0.8em) – sm" type = "text" content = "About Kaiser Permanente
Kaiser Permanente is committed to shaping the future of health care. We are recognized as one of America & # 39; s leading health care providers and non-profit health plans. Kaiser Permanente, founded in 1945, has a mission to provide high-quality affordable health care and to improve the health of our members and the communities we serve. We currently serve more than 12.2 million members in eight states and the District of Columbia. Care for members and patients is focused on their total health and is supervised by their personal Permanent Medical Group doctors, specialists and a team of caregivers. Our expert and caring medical teams are empowered and supported by leading technological developments and tools for health promotion, disease prevention, advanced care and world-class chronic disease management. Kaiser Permanente is committed to healthcare innovations, clinical research, health education and support for public health. For more information, go to: & nbsp;kp.org/share. "data reactid =" 38 ">About Kaiser Permanente
Kaiser Permanente is committed to shaping the future of health care. We are recognized as one of America & # 39; s leading health care providers and non-profit health plans. Kaiser Permanente, founded in 1945, has a mission to provide high-quality affordable health care and to improve the health of our members and the communities we serve. We currently serve more than 12.2 million members in eight states and the District of Columbia. Care for members and patients is focused on their total health and is supervised by their personal Permanent Medical Group doctors, specialists and a team of caregivers. Our expert and caring medical teams are empowered and supported by leading technological developments and tools for health promotion, disease prevention, advanced care and world-class chronic disease management. Kaiser Permanente is committed to healthcare innovations, clinical research, health education and support for public health. For more information, go to: kp.org/share.

<p class = "canvas-atom canvas-text Mb (1.0em) Mb (0) – sm Mt (0.8em) – sm" type = "text" content = "For more information contact:
Jonathan Fine, [email protected], 503-528-3997
Heather Platisha, [email protected], 415-262-5992 "data reactid =" 39 ">For more information contact:
Jonathan Fine, [email protected], 503-528-3997
Heather Platisha, [email protected], 415-262-5992

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